Human solute carrier family 34 (sodium phosphate) , member 1 ELISA Kit | SLC34A1 elisa kit
Human Sodium-dependent phosphate transport protein 2A, SLC34A1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Description
SLC34A1: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1). Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization). Defects in SLC34A1 are the cause of Fanconi renotubular syndrome type 2 (FRTS2). It is a disease resulting from a generalized dysfunction of the proximal kidney tubule leading to decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: cell surface; brush border membrane; integral to plasma membrane; perinuclear region of cytoplasm; basolateral plasma membrane; apical plasma membrane; plasma membrane; endosome; lipid raft
Molecular Function: protein binding; protein homodimerization activity; symporter activity; protein complex binding; sodium-dependent phosphate transmembrane transporter activity; PDZ domain binding
Biological Process: indole metabolic process; response to drug; ossification; glycoprotein metabolic process; sodium ion transport; bone remodeling; response to estradiol stimulus; response to vitamin A; response to mercury ion; response to magnesium ion; response to cadmium ion; phosphate transport; response to lead ion; ion transport; phosphate ion homeostasis; positive regulation of membrane potential; kidney development; transmembrane transport; protein homooligomerization
Disease: Fanconi Renotubular Syndrome 2; Nephrolithiasis/osteoporosis, Hypophosphatemic, 1
Research Articles on SLC34A1
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Product Notes
The Human SLC34A1 slc34a1 (Catalog #AAA9330811) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330811 ELISA Kit recognizes Human SLC34A1. It is sometimes possible for the material contained within the vial of "solute carrier family 34 (sodium phosphate) , member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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