Very long-chain acyl-CoA synthetase Recombinant Protein | S27A2 recombinant protein
Recombinant Human Very long-chain acyl-CoA synthetase
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Description
SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to peroxisomal membrane; peroxisomal membrane; plasma membrane
Molecular Function: enzyme binding; long-chain-fatty-acid-CoA ligase activity; phytanate-CoA ligase activity; receptor binding; very-long-chain-fatty-acid-CoA ligase activity
Biological Process: bile acid biosynthetic process; fatty acid alpha-oxidation; fatty acid beta-oxidation; long-chain fatty acid metabolic process; neutrophil degranulation
Research Articles on S27A2
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Product Notes
The S27A2 slc27a2 (Catalog #AAA9422498) is a Recombinant Protein produced from Yeast and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Cytoplasmic Domain, 283-620aa. The Recombinant Human Very long-chain acyl-CoA synthetase reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Very long-chain acyl-CoA synthetase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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