solute carrier family 22 (organic anion/urate transporter) , member 12 ELISA Kit | SLC22A12 elisa kit
Rat Solute carrier family 22 member 12, SLC22A12 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may act as an anion transporter; mRNA is expressed exclusively in kidney [RGD, Feb 2006]
Uniprot Description
SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: brush border membrane; apical plasma membrane; plasma membrane; integral to membrane
Molecular Function: urate transmembrane transporter activity; PDZ domain binding
Biological Process: response to drug; urate transport; urate metabolic process; organic acid transport; transmembrane transport
Research Articles on SLC22A12
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Product Notes
The Rat SLC22A12 slc22a12 (Catalog #AAA9339093) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339093 ELISA Kit recognizes Rat SLC22A12. It is sometimes possible for the material contained within the vial of "solute carrier family 22 (organic anion/urate transporter) , member 12, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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