Mouse solute carrier family 11 (proton-coupled divalent metal ion transporters) , member 2 ELISA Kit | SLC11A2 elisa kit
Mouse Natural resistance-associated macrophage protein 2, SLC11A2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SLC11A2: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Defects in SLC11A2 are a cause of hypochromic microcytic anemia (HCMA). The disease is characterized by an abnormal hemoglobin content in the erythrocytes which are reduced in size. It may be hereditary or acquired. Mutations in SLC11A2 are associated with progressive liver iron overload and normal to moderately elevated serum ferritin levels. Belongs to the NRAMP family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cell surface; mitochondrion; late endosome membrane; lysosomal membrane; integral to plasma membrane; lysosome; early endosome; integral to membrane; endomembrane system; trans-Golgi network; mitochondrial outer membrane; recycling endosome; membrane; perinuclear region of cytoplasm; apical part of cell; late endosome; apical plasma membrane; cytoplasm; plasma membrane; vacuole; cytoplasmic vesicle; nucleus; brush border; endosome
Molecular Function: cadmium ion transmembrane transporter activity; nickel ion transmembrane transporter activity; iron ion transmembrane transporter activity; inorganic cation transmembrane transporter activity; zinc ion binding; transporter activity; manganese ion transmembrane transporter activity; hydrogen ion transmembrane transporter activity; cadmium ion binding; vanadium ion transmembrane transporter activity; nickel ion binding; copper ion transmembrane transporter activity; copper ion binding; manganese ion binding; iron ion binding; cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; lead ion transmembrane transporter activity; cobalt ion binding; solute:hydrogen symporter activity
Biological Process: lead ion transport; caspase activation; erythrocyte development; transition metal ion transport; cellular copper ion homeostasis; dendrite morphogenesis; manganese ion transport; copper ion transport; porphyrin biosynthetic process; iron ion transport; response to manganese ion; nickel ion transport; proton transport; iron ion homeostasis; learning and/or memory; transport; vanadium ion transport; ferrous iron transport; porphyrin metabolic process; ion transport; cobalt ion transport; heme biosynthetic process
Research Articles on SLC11A2
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Product Notes
The Mouse SLC11A2 slc11a2 (Catalog #AAA9320823) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320823 ELISA Kit recognizes Mouse SLC11A2. It is sometimes possible for the material contained within the vial of "solute carrier family 11 (proton-coupled divalent metal ion transporters) , member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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