Human solute carrier family 10 (sodium/bile acid cotransporter family) , member 2 ELISA Kit | SLC10A2 elisa kit
Human Ileal sodium/bile acid cotransporter, SLC10A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
Uniprot Description
ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q33
Cellular Component: proteasome complex; microvillus; integral to plasma membrane; apical plasma membrane; plasma membrane; nucleus
Molecular Function: bile acid:sodium symporter activity
Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; sodium ion transport; transmembrane transport
Disease: Bile Acid Malabsorption, Primary
Research Articles on SLC10A2
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Product Notes
The Human SLC10A2 slc10a2 (Catalog #AAA9320817) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320817 ELISA Kit recognizes Human SLC10A2. It is sometimes possible for the material contained within the vial of "solute carrier family 10 (sodium/bile acid cotransporter family) , member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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