SKI2W Blocking Peptide | SKIV2L blocking peptide

SKI2W Peptide

Cat. Num. AAA154484

• Gene Names: SKIV2L; HLP; 170A; SKI2; DDX13; SKI2W; SKIV2; THES2; SKIV2L1
• Applications: Blocking (BL)
• Synonyms: SKI2W; SKI2W Peptide; Superkiller viralicidic activity 2-like; DDX13; Helicase-like protein; Helicase SKI2W; HLP; SKI2; SKIV2; SKIV2L; SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae); SKIV2L blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Positions: 16 amino acid peptide near the amino terminus of human SKI2W.
• Sequence: REDPNSRSRFRSKKEV
• Sequence Length: 1246

• Applicable Applications for SKIV2L blocking peptide: Blocking (BL)
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Species: Human
• Preparation and Storage: Store at -20 degree C, stable for one year.

References

1. Dangel AW, Shen L, Mendoza AR, et al. Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family. Nucleic Acids Res. 1995; 23:2120-6. 2. Qu X, Yang Z, Zhang S, et al. The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes. Nucleic Acids Res. 1998; 26:4068-77. 3. Yang Z, Shen L, Dangel AW, et al. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. Genomics 1998; 53:338-47. 4. Yang Z, Qu X, and Yu CY. Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region. Front. Biosci. 2001; 6:D927-35.

NCBI and Uniprot Product Information

• NCBI GI #: 67782311
• NCBI GeneID: 6499
• NCBI Accession #: NP_008860
• NCBI GenBank Nucleotide #: NM_006929.4
• UniProt Accession #: Q15477; O15005; Q12902; Q15476; Q5ST66
• Molecular Weight: 137,755 Da
• NCBI Official Full Name: helicase SKI2W
• NCBI Official Synonym Full Names: Ski2 like RNA helicase
• NCBI Official Symbol: SKIV2L
• NCBI Official Synonym Symbols: HLP; 170A; SKI2; DDX13; SKI2W; SKIV2; THES2; SKIV2L1
• NCBI Protein Information: helicase SKI2W
• UniProt Protein Name: Helicase SKI2W
• Protein Family: Helicase
• UniProt Gene Name: SKIV2L
• UniProt Synonym Gene Names: DDX13; SKI2W; SKIV2; W; Ski2; HLP

NCBI Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Uniprot Description

SKI2W: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Defects in SKIV2L are the cause of trichohepatoenteric syndrome type 2 (THES2). A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients. Belongs to the helicase family. SKI2 subfamily.

Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: cytosol

Molecular Function: ATP-dependent RNA helicase activity

Disease: Trichohepatoenteric Syndrome 2