Typical Testing Data/Standard Curve (for reference only)
Mouse NAD-dependent deacetylase sirtuin-2 ELISA Kit | Sirt2 elisa kit
Mouse NAD-dependent deacetylase sirtuin-2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
SIRT2: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.-; Deacetylase
Cellular Component: cell projection; centriole; centrosome; chromosome; cytoplasm; cytoskeleton; cytosol; lateral loop; membrane; microtubule; midbody; myelin sheath; nuclear heterochromatin; nucleus; paranode region of axon; perikaryon; perinuclear region of cytoplasm; plasma membrane; spindle
Molecular Function: (3,5-dichlorophenylurea)acetate amidohydrolase activity; beta-tubulin binding; chromatin binding; histone acetyltransferase binding; histone deacetylase activity; histone deacetylase binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; indoleacetamide hydrolase activity; iprodione amidohydrolase activity; metal ion binding; N-acetylgalactosamine-6-phosphate deacetylase activity; N2-acetyl-L-lysine deacetylase activity; NAD binding; NAD-dependent histone deacetylase activity (H4-K16 specific); O-succinylbenzoate synthase activity; protein binding; protein deacetylase activity; protein N-terminal asparagine amidohydrolase activity; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; zinc ion binding
Biological Process: autophagy; cell cycle; cell differentiation; cell division; cellular lipid catabolic process; hepatocyte growth factor receptor signaling pathway; histone deacetylation; meiotic cell cycle; mitosis; myelination in the peripheral nervous system; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of protein catabolic process; negative regulation of striated muscle development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; phosphoinositide 3-kinase cascade; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell division; positive regulation of DNA binding; positive regulation of meiosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid deacetylation; protein kinase B signaling cascade; regulation of cell cycle; regulation of fat cell differentiation; regulation of myelination; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on Sirt2
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Product Notes
The Mouse Sirt2 sirt2 (Catalog #AAA2883621) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2883621 ELISA Kit recognizes Mouse Sirt2. It is sometimes possible for the material contained within the vial of "NAD-dependent deacetylase sirtuin-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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