NAD-dependent histone deacetylase SIR2 (SIR2) Recombinant Protein | SIR2 recombinant protein
Recombinant Saccharomyces cerevisiae NAD-dependent histone deacetylase SIR2 (SIR2) , partial
NCBI and Uniprot Product Information
Uniprot Description
NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential.
Research Articles on SIR2
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Product Notes
The SIR2 sir2 (Catalog #AAA1032349) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 245-529. partial. The amino acid sequence is listed below: DHFIQKLHTA RKILVLTGAG VSTSLGIPDF RSSEGFYSKI KHLGLDDPQD VFNYNIFMHD PSVFYNIANM VLPPEKIYSP LHSFIKMLQM KGKLLRNYTQ NIDNLESYAG ISTDKLVQCH GSFATATCVT CHWNLPGERI FNKIRNLELP LCPYCYKKRR EYFPEGYNNK VGVAASQGSM SERPPYILNS YGVLKPDITF FGEALPNKFH KSIREDILEC DLLICIGTSL KVAPVSEIVN MVPSHVPQVL INRDPVKHAE FDLSLLGYCD DIAAMVAQKC GWTIP . It is sometimes possible for the material contained within the vial of "NAD-dependent histone deacetylase SIR2 (SIR2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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