Cell invasion protein sipB (sipB) Recombinant Protein | sipB recombinant protein

Recombinant Salmonella dublin Cell invasion protein sipB (sipB), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cell invasion protein sipB (sipB); Recombinant Salmonella dublin Cell invasion protein sipB (sipB); partial; sipB recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 593

• Species: Salmonella dublin
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 446167933
• NCBI Accession #: WP_000245788.1
• NCBI GenBank Nucleotide #: WP_000245788.1
• UniProt Accession #: Q79BT1
• Molecular Weight: 62,451 Da
• NCBI Official Full Name: SPI-1 type III secretion system needle tip complex protein SipB
• UniProt Protein Name: Cell invasion protein SipB
• Protein Family: Cell invasion protein
• UniProt Gene Name: sipB

Uniprot Description

Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE ().