Human survival of motor neuron protein interacting protein 1 ELISA Kit | SIP1 elisa kit
Human Survival of motor neuron protein-interacting protein 1, SIP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]
Uniprot Description
SIP1: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing
Chromosomal Location of Human Ortholog: 14q13
Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; SMN complex; nucleus; cytosol
Molecular Function: protein binding
Biological Process: RNA splicing, via transesterification reactions; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression; mRNA processing
Research Articles on SIP1
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Product Notes
The Human SIP1 gemin2 (Catalog #AAA9322699) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322699 ELISA Kit recognizes Human SIP1. It is sometimes possible for the material contained within the vial of "survival of motor neuron protein interacting protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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