Human single-minded homolog 2 (Drosophila) ELISA Kit | SIM2 elisa kit
Human Single-minded homolog 2, SIM2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq, Jul 2008]
Uniprot Description
SIM2: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; DNA-binding
Chromosomal Location of Human Ortholog: 21q22.13
Cellular Component: nucleoplasm
Molecular Function: signal transducer activity; DNA binding; protein heterodimerization activity; transcription factor activity
Biological Process: nervous system development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; cell differentiation; signal transduction; lung development
Research Articles on SIM2
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Product Notes
The Human SIM2 sim2 (Catalog #AAA9343213) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343213 ELISA Kit recognizes Human SIM2. It is sometimes possible for the material contained within the vial of "single-minded homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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