Rat SIgMa Non-Opioid Intracellular Receptor 1 ELISA Kit | SIGMAR1 elisa kit
Rat SIgMa Non-Opioid Intracellular Receptor 1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2008]
Uniprot Description
SIGMAR1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Defects in SIGMAR1 are the cause of amyotrophic lateral sclerosis type 16, juvenile (ALS16). ALS16 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. Belongs to the ERG2 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Nuclear envelope; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; growth cone; integral to plasma membrane; integral to membrane; nuclear inner membrane; lipid particle; nuclear envelope; cell junction
Molecular Function: opioid receptor activity; drug binding
Biological Process: nervous system development; regulation of neuron apoptosis; lipid transport
Disease: Amyotrophic Lateral Sclerosis 16, Juvenile
Research Articles on SIGMAR1
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Product Notes
The Rat SIGMAR1 sigmar1 (Catalog #AAA033241) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA033241 ELISA Kit recognizes Rat SIGMAR1. It is sometimes possible for the material contained within the vial of "SIgMa Non-Opioid Intracellular Receptor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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