Sialic acid-binding Ig-like lectin 12 (Siglec12) Recombinant Protein | Siglec12 recombinant protein

Recombinant Mouse Sialic acid-binding Ig-like lectin 12 (Siglec12), partial

Cat. Num. AAA1447317

• Gene Names: Siglece; Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sialic acid-binding Ig-like lectin 12 (Siglec12); Recombinant Mouse Sialic acid-binding Ig-like lectin 12 (Siglec12); partial; Siglec12 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 19-353
• Sequence: QN PQEVFTLNVE RKVVVQEGLC VLVPCNFSYL KKRLTDWTDS DPVHGFWYRE GTDRRKDSIV ATNNPIRKAV KETRNRFFLL GDPWRNDCSL NIREIRKKDA GLYFFRLERG KTKYNYMWDK MTLVVTALTN TPQILLPETL EAGHPSNLTC SVPWDCGWTA PPIFSWTGTS VSFLSTNTTG SSVLTITPQP QDHGTNLTCQ VTLPGTNVST RMTIRLNVSY APKNLTVTIY QGADSVSTIL KNGSSLPISE GQSLRLICST DSYPPANLSW SWDNLTLCPS KLSKPGLLEL FPVHLKHGGV YTCQAQHALG SQHISLSLSP QSSATLSEMM MGT
• Sequence Length: 335

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Siglec12 recombinant protein

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 134032002
• NCBI GeneID: 83382
• NCBI Accession #: NP_112458.2
• NCBI GenBank Nucleotide #: NM_031181.2
• UniProt Accession #: Q91Y57; E9QMD1
• Molecular Weight: 51,901 Da
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 12
• NCBI Official Synonym Full Names: sialic acid binding Ig-like lectin E
• NCBI Official Symbol: Siglece
• NCBI Official Synonym Symbols: Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E
• NCBI Protein Information: sialic acid-binding Ig-like lectin 12
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 12
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: Siglec12
• UniProt Synonym Gene Names: Siglec5; Siglece; Siglecl1; Siglec-12; MIS; Siglec-5; Siglec-E; mSiglec-E; Siglec-L1

Uniprot Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.