Sialic acid-binding Ig-like lectin 11 (SIGLEC11) Recombinant Protein | SIGLEC11 recombinant protein
Recombinant Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11), partial
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Research Articles on SIGLEC11
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Product Notes
The SIGLEC11 siglec11 (Catalog #AAA1431469) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 28-28-561aa; Extracellular Domain. The amino acid sequence is listed below: LNKDPSYSLQ VQRQVPVPEG LCVIVSCNLS YPRDGWDEST AAYGYWFKGR TSPKTGAPVA TNNQSREVEM STRDRFQLTG DPGKGSCSLV IRDAQREDEA WYFFRVERGS RVRHSFLSNA FFLKVTALTK KPDVYIPETL EPGQPVTVIC VFNWAFKKCP APSFSWTGAA LSPRRTRPST SHFSVLSFTP SPQDHDTDLT CHVDFSRKGV SAQRTVRLRV AYAPKDLIIS ISHDNTSALE LQGNVIYLEV QKGQFLRLLC AADSQPPATL SWVLQDRVLS SSHPWGPRTL GLELRGVRAG DSGRYTCRAE NRLGSQQQAL DLSVQYPPEN LRVMVSQANR TVLENLGNGT SLPVLEGQSL RLVCVTHSSP PARLSWTRWG QTVGPSQPSD PGVLELPPIQ MEHEGEFTCH AQHPLGSQHV SLSLSVHYPP QLLGPSCSWE AEGLHCSCSS QASPAPSLRW WLGEELLEGN SSQGSFEVTP SSAGPWANSS LSLHGGLSSG LRLRCKAWNV HGAQSGSVFQ LLPGKLEHGG GLGL . It is sometimes possible for the material contained within the vial of "Sialic acid-binding Ig-like lectin 11 (SIGLEC11), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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