Rabbit anti-Human Siglec11 Polyclonal Antibody | anti-Siglec11 antibody

Siglec11 Antibody

Cat. Num. AAA9414034

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Siglec11; Polyclonal Antibody; Siglec11 Antibody; Sialic acid binding Ig-like lectin 11; anti-Siglec11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 698

• Applicable Applications for anti-Siglec11 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 18 amino acid peptide from near the carboxy terminus of human Siglec11.
• Target Name: Siglec11
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Siglec11 in HepG2 cell lysate with Siglec11 antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Siglec11 in human liver tissue with Siglec11 antibody at 5 ug/mL.)

Related Product Information for anti-Siglec11 antibody

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist. Siglec11 antibody will not cross-react with Siglec10.

Product Categories/Family for anti-Siglec11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 205830470
• NCBI GeneID: 114132
• NCBI Accession #: NP_443116
• NCBI GenBank Nucleotide #: NM_052884.2
• Molecular Weight: 65,818 Da
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 11 isoform 1
• NCBI Official Synonym Full Names: sialic acid binding Ig-like lectin 11
• NCBI Official Symbol: SIGLEC11
• NCBI Protein Information: sialic acid-binding Ig-like lectin 11
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 11
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC11
• UniProt Synonym Gene Names: Sialic acid-binding lectin 11; Siglec-11
• UniProt Entry Name: SIG11_HUMAN

NCBI Description

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

SIGLEC11: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: integral to membrane

Molecular Function: carbohydrate binding

Biological Process: cell adhesion