Human SNF2 histone linker PHD RING helicase ELISA Kit | SHPRH elisa kit
Human E3 ubiquitin-protein ligase SHPRH, SHPRH ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
Uniprot Description
SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; EC 3.6.1.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 3.6.4.-; Helicase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 6q24.3
Cellular Component: nucleosome; nucleus
Molecular Function: DNA binding; zinc ion binding; ubiquitin-protein ligase activity; helicase activity; ATP binding; ligase activity
Biological Process: nucleosome assembly; protein polyubiquitination; DNA repair
Research Articles on SHPRH
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Product Notes
The Human SHPRH shprh (Catalog #AAA9329561) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329561 ELISA Kit recognizes Human SHPRH. It is sometimes possible for the material contained within the vial of "SNF2 histone linker PHD RING helicase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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