Testing Data
Mouse anti-Human SHPRH Monoclonal Antibody | anti-SHPRH antibody
SHPRH (SNF2 Histone-linker PHD RING-finger Helicase, 2610103K11RIK, bA545I5.2, FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM]
Uniprot Description
SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Helicase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 3.6.4.-; EC 3.6.1.-
Chromosomal Location of Human Ortholog: 6q24.3
Cellular Component: nucleosome; nucleus
Molecular Function: DNA binding; zinc ion binding; ubiquitin-protein ligase activity; helicase activity; ATP binding; ligase activity
Biological Process: nucleosome assembly; protein polyubiquitination; DNA repair
Research Articles on SHPRH
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Product Notes
The SHPRH shprh (Catalog #AAA605817) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SHPRH (SNF2 Histone-linker PHD RING-finger Helicase, 2610103K11RIK, bA545I5.2, FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SHPRH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the SHPRH shprh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHPRH, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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