Mouse Soluble Leukocyte antigen G ELISA Kit | sHLA-G elisa kit
Mouse Soluble Leukocyte antigen G ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
SMAD1: transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: nucleoplasm; transcription factor complex; protein complex; cytoplasm; integral to membrane; nuclear inner membrane; intracellular; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; metal ion binding; receptor signaling protein activity; transcription factor activity; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: response to drug; wound healing; transcription, DNA-dependent; MAPKKK cascade; cardiac muscle cell proliferation; positive regulation of dendrite morphogenesis; primary microRNA processing; embryonic pattern specification; signal transduction; response to organic nitrogen; protein amino acid phosphorylation; SMAD protein complex assembly; mesodermal cell fate commitment; BMP signaling pathway; negative regulation of cell proliferation; positive regulation of osteoblast differentiation; homeostatic process; ureteric bud development; transforming growth factor beta receptor signaling pathway; cartilage development; gamete generation; midbrain development; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; hindbrain development; osteoblast fate commitment
Research Articles on sHLA-G
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Product Notes
The Mouse sHLA-G smad1 (Catalog #AAA728237) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA728237 ELISA Kit recognizes Mouse sHLA-G. It is sometimes possible for the material contained within the vial of "Soluble Leukocyte antigen G, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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