Activity
(Specific Activity: Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.)
SHIP1 recombinant protein
SHIP1, Active
Applications
Western Blot
Synonyms
SHIP1; Active; INPP5D; SHIP; hp51CN; SIP-145; MGC142140; MGC142142; SHIP1 recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 20mM MOPS, pH7.5, 300mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for SHIP1 recombinant protein
Phosphatase Assay, Western Blot (WB)
Tag
GST
Species
Human
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Activity
(Specific Activity: Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Related Product Information for SHIP1 recombinant protein
Recombinant full length human SHIP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_005541.
The SH2-containing inositol-5?-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.
The SH2-containing inositol-5?-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.
Product Categories/Family for SHIP1 recombinant protein
References
1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.
2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438-445, 1996.
2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438-445, 1996.
NCBI and Uniprot Product Information
Similar Products
Product Notes
The SHIP1 (Catalog #AAA517369) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SHIP1 can be used in a range of immunoassay formats including, but not limited to, Phosphatase Assay, Western Blot (WB). Researchers should empirically determine the suitability of the SHIP1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHIP1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
