SH3 and multiple ankyrin repeat domains protein 3 (Shank3) Recombinant Protein | Shank3 recombinant protein

Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 3 (Shank3) , partial

• Gene Names: Shank3; Shank3b; AI841104; SHANK3c-3; SHANK3c-4
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: SH3 and multiple ankyrin repeat domains protein 3 (Shank3); Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 3 (Shank3); partial; Shank3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 840

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Shank3 recombinant protein

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD) which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene are a major causitive factor in the neurological symptoms of 22q13.3 deletion syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

NCBI and Uniprot Product Information

• NCBI GI #: 71896543
• NCBI GeneID: 58234
• NCBI Accession #: NP_067398.2
• NCBI GenBank Nucleotide #: NM_021423.3
• UniProt Accession #: Q4ACU6; Q69ZD8; Q9JJZ3; F8S0X0; F8S0X2; F8S0X3; F8S0X5; F8S0X6; S6BMD3; S6CCV8
• Molecular Weight: 88,196 Da
• NCBI Official Full Name: SH3 and multiple ankyrin repeat domains protein 3
• NCBI Official Synonym Full Names: SH3 and multiple ankyrin repeat domains 3
• NCBI Official Symbol: Shank3
• NCBI Official Synonym Symbols: Shank3b; AI841104; SHANK3c-3; SHANK3c-4
• NCBI Protein Information: SH3 and multiple ankyrin repeat domains protein 3
• UniProt Protein Name: SH3 and multiple ankyrin repeat domains protein 3
• Protein Family: SH3 and multiple ankyrin repeat domains protein
• UniProt Gene Name: Shank3
• UniProt Synonym Gene Names: Kiaa1650; Prosap2; Shank3; ProSAP2

Uniprot Description

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.