Potassium voltage-gated channel protein Shal (Shal) Recombinant Protein | Shal recombinant protein

Recombinant Drosophila melanogaster Potassium voltage-gated channel protein Shal (Shal)

• Gene Names: Shal; CG9262; DmelCG9262; dShal; Sh-l; shal; Shl
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Potassium voltage-gated channel protein Shal (Shal); Recombinant Drosophila melanogaster Potassium voltage-gated channel protein Shal (Shal); Recombinant Potassium voltage-gated channel protein Shal (Shal); Potassium voltage-gated channel protein Shal; Shaker cognate l Shal2; Shal recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-571
• Sequence: MASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNSQNNQPMDGTYLVEASF
• Sequence Length: 571

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 161084970
• NCBI GeneID: 40129
• NCBI Accession #: NP_001097646.1
• NCBI GenBank Nucleotide #: NM_001104176.1
• UniProt Accession #: P17971; Q29R37; Q9VW11; A8JNV8; AAF49144
• Molecular Weight: 64,570 Da
• NCBI Official Full Name: shaker cognate l, isoform B
• NCBI Official Synonym Full Names: Shaker cognate l
• NCBI Official Symbol: Shal
• NCBI Official Synonym Symbols: CG9262; DmelCG9262; dShal; Sh-l; shal; Shl
• NCBI Protein Information: CG9262 gene product from transcript CG9262-RB; CG9262-PA; CG9262-PB; Shaker-like; Shal-PA; Shal-PB; shaker cognate 1; shaker cognate l
• UniProt Protein Name: Potassium voltage-gated channel protein Shal
• Protein Family: Potassium voltage-gated channel protein
• UniProt Gene Name: Shal
• UniProt Synonym Gene Names: SHAL2
• UniProt Entry Name: KCNAL_DROME

Uniprot Description

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells.

Subunit structure: Heterotetramer of potassium channel proteins

By similarity. Interacts (via C-terminal dendritic targeting motif) with SIDL. Ref.6

Subcellular location: Membrane; Multi-pass membrane protein. Cell projection › dendrite. Perikaryon.

Tissue specificity: Co-expressed with SIDL in the nervous system. Ref.6

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Miscellaneous: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Shal sub-subfamily. [View classification]