SH3 domain-containing kinase-binding protein 1 (Sh3kbp1) Recombinant Protein | Sh3kbp1 recombinant protein

Recombinant Rat SH3 domain-containing kinase-binding protein 1 (Sh3kbp1)

Cat. Num. AAA1329219

• Gene Names: Sh3kbp1; Seta; CIN85
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: SH3 domain-containing kinase-binding protein 1 (Sh3kbp1); Recombinant Rat SH3 domain-containing kinase-binding protein 1 (Sh3kbp1); Sh3kbp1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-709, full length protein
• Sequence: MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDVKKDLLSNKAPEKPMHDVSSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLNRPGVLPPRRPERPVGPLTHTRGDSSKIDLAGSTLSGILDKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGIDVSKKTSRTVTISQVSDNKASLPPKPGTMAAASSGPASLSSVASSPMSSSLGTAGQRASSPSLFSAEGKAKTESAVSSQAAIEELKMQVRELRTIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
• Sequence Length: 709

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 29789297
• NCBI GeneID: 84357
• NCBI Accession #: NP_445812.1
• NCBI GenBank Nucleotide #: NM_053360.2
• UniProt Accession #: Q925Q9; Q925R0; Q925R1; Q925R2; Q925R3; Q9JKQ0; Q9JKQ1; Q9JLU9
• Molecular Weight: 64,847 Da
• NCBI Official Full Name: SH3 domain-containing kinase-binding protein 1
• NCBI Official Synonym Full Names: SH3 domain-containing kinase-binding protein 1
• NCBI Official Symbol: Sh3kbp1
• NCBI Official Synonym Symbols: Seta; CIN85
• NCBI Protein Information: SH3 domain-containing kinase-binding protein 1
• UniProt Protein Name: SH3 domain-containing kinase-binding protein 1
• Protein Family: SH3 domain-containing kinase-binding protein
• UniProt Gene Name: Sh3kbp1
• UniProt Synonym Gene Names: Ruk; Seta; Ruk

NCBI Description

binds apoptosis-linked gene 2 (ALG-2) interacting protein 1; involved in regulation of apoptosis in astrocytes [RGD, Feb 2006]

Uniprot Description

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor (). Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration ().