Alpha-sarcoglycan Recombinant Protein | Sgca recombinant protein
Alpha-sarcoglycan
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012]
Uniprot Description
SGCA: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: dystroglycan complex; integral to plasma membrane; intercellular junction; lipid raft; sarcoglycan complex; sarcolemma
Biological Process: muscle system process
Research Articles on Sgca
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Product Notes
The Sgca sgca (Catalog #AAA7043315) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-387aa; full length protein. The amino acid sequence is listed below: QQTTLHLLVG RVFVHPLEHA TFLRLPEHVA VPPTVRLTYH AHLQGHPDLP RWLHYTQRSP YNPGFLYGSP TPEDRGYQVI EVTAYNRDSF DTTRQRLLLL IGDPEGPRLP YQAEFLVRSH DVEEVLPTTP ANRFLTALGG LWEPGELQLL NITSALDRGG RVPLPIEGRK EGVYIKVGSA TPFSTCLKMV ASPDSYARCA QGQPPLLSCY DTLAPHFRVD WCNVSLVDKS VPEPLDEVPT PGDGILEHDP FFCPPTEATD RDFLTDALVT LLVPLLVALL LTLLLAYIMC FRREGRLKRD MATSDIQMFH HCSIHGNTEE LRQMAASREV PRPLSTLPMF NVRTGERLPP RVDSAQMPLI LDQH. It is sometimes possible for the material contained within the vial of "Alpha-sarcoglycan, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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