Surfactant Protein A Blocking Peptide | SFTPA2 blocking peptide

Surfactant Protein A Blocking Peptide

Cat. Num. AAA9622107

• Gene Names: SFTPA2; PSAP; PSPA; SP-A; SPA2; PSP-A; SFTP1; SPAII; COLEC5; SFTPA2B
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: Surfactant Protein A; Surfactant Protein A Blocking Peptide; SFTPA2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SFTPA2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SFTPA2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 148886696
• NCBI GeneID: 729238
• NCBI Accession #: NP_001092138.1
• NCBI GenBank Nucleotide #: NP_001092138.1
• UniProt Accession #: Q8IWL1; P07714; Q14DV3; Q5RIR8; A4QPA7; B2RXI6; B2RXK9; C9J9I7; E3VLC6; E3VLC7; E3VLC8; E3VLC9
• Molecular Weight: 26,182 Da
• NCBI Official Full Name: pulmonary surfactant-associated protein A2 isoform 1
• NCBI Official Synonym Full Names: surfactant protein A2
• NCBI Official Symbol: SFTPA2
• NCBI Official Synonym Symbols: PSAP; PSPA; SP-A; SPA2; PSP-A; SFTP1; SPAII; COLEC5; SFTPA2B
• NCBI Protein Information: pulmonary surfactant-associated protein A2
• UniProt Protein Name: Pulmonary surfactant-associated protein A2
• Protein Family: Pulmonary surfactant-associated protein
• UniProt Gene Name: SFTPA2
• UniProt Synonym Gene Names: COLEC5; PSAP; SFTP1; SFTPA; SFTPA2B; PSP-A; PSPA; SP-A; SP-A2
• UniProt Entry Name: SFPA2_HUMAN

NCBI Description

This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]

Uniprot Description

SFTPA2: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Belongs to the SFTPA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: clathrin-coated endocytic vesicle; collagen; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body; proteinaceous extracellular matrix

Molecular Function: carbohydrate binding

Biological Process: cellular protein metabolic process; respiratory gaseous exchange

Disease: Pulmonary Fibrosis, Idiopathic