CD105, sf9 Active Protein
CD105, Recombinant, Human, sf9 (Endoglin, gp160, TGF beta1,3 Receptor, ENG, END, ORW, HHT1, ORW1, FLJ41744)
Purity
Purified95%. Analysis by RP-HPLC., SDS-PAGE.
Synonyms
CD105; sf9; Recombinant; Human; sf9 (Endoglin; gp160; TGF beta1; 3 Receptor; ENG; END; ORW; HHT1; ORW1; FLJ41744); sf9 active protein
Host
Sf9 Insect Cells
Purity/Purification
Purified
95%. Analysis by RP-HPLC., SDS-PAGE.
95%. Analysis by RP-HPLC., SDS-PAGE.
Form/Format
Supplied as a lyophilized powder from a concentrated (1mg/ml) sterile solution containing no additives.
Application Notes
Suitable for use in ELISA, Inhibition Assays and Western Blot. Other applicatios not tested.
Biological Activity
Measured by its ability to bind with rhTGF-beta RII/Fc in a functional ELISA.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS, 0.1% HSA or BSA. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for CD105, sf9 active protein
CD105 (26-176 a.a.) or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. It exists as an O- and N-glycosylated homodimer of 180kD. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF beta3, activin-A, BMP-2, and BMP-7. CD105 binds to TGF Beta1 and Beta3 with high affinity but not TGF-Beta2Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 586 amino acids and having a molecular mass of 61kD but as a result of glycosylation, migrates at 90kD under reducing conditions in SDS-PAGE.
CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 586 amino acids and having a molecular mass of 61kD but as a result of glycosylation, migrates at 90kD under reducing conditions in SDS-PAGE.
Product Categories/Family for CD105, sf9 active protein
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Product Notes
The CD105, sf9 (Catalog #AAA635662) is an Active Protein produced from Sf9 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. Suitable for use in ELISA, Inhibition Assays and Western Blot. Other applicatios not tested. Researchers should empirically determine the suitability of the CD105, sf9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD105, sf9, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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