Splicing factor 1 (SF1) Recombinant Protein | SF1 recombinant protein
Recombinant Human Splicing factor 1 (SF1)
Gene Names
SF1; BBP; MBBP; ZFM1; ZNF162; D11S636; ZCCHC25
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Splicing factor 1 (SF1); Recombinant Human Splicing factor 1 (SF1); SF1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-639aa; Full Length of Mature Protein
Sequence
ATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65,371 Da
NCBI Official Full Name
splicing factor 1 isoform 6
NCBI Official Synonym Full Names
splicing factor 1
NCBI Official Symbol
SF1
NCBI Official Synonym Symbols
BBP; MBBP; ZFM1; ZNF162; D11S636; ZCCHC25
NCBI Protein Information
splicing factor 1
UniProt Protein Name
Splicing factor 1
Protein Family
UniProt Gene Name
SF1
UniProt Synonym Gene Names
ZFM1; ZNF162; BBP; mBBP
NCBI Description
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Description
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Research Articles on SF1
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Product Notes
The SF1 sf1 (Catalog #AAA1368210) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-639aa; Full Length of Mature Protein. The amino acid sequence is listed below: ATGANATPLD FPSKKRKRSR WNQDTMEQKT VIPGMPTVIP PGLTREQERA YIVQLQIEDL TRKLRTGDLG IPPNPEDRSP SPEPIYNSEG KRLNTREFRT RKKLEEERHN LITEMVALNP DFKPPADYKP PATRVSDKVM IPQDEYPEIN FVGLLIGPRG NTLKNIEKEC NAKIMIRGKG SVKEGKVGRK DGQMLPGEDE PLHALVTANT MENVKKAVEQ IRNILKQGIE TPEDQNDLRK MQLRELARLN GTLREDDNRI LRPWQSSETR SITNTTVCTK CGGAGHIASD CKFQRPGDPQ SAQDKARMDK EYLSLMAELG EAPVPASVGS TSGPATTPLA SAPRPAAPAN NPPPPSLMST TQSRPPWMNS GPSESRPYHG MHGGGPGGPG GGPHSFPHPL PSLTGGHGGH PMQHNPNGPP PPWMQPPPPP MNQGPHPPGH HGPPPMDQYL GSTPVGSGVY RLHQGKGMMP PPPMGMMPPP PPPPSGQPPP PPSGPLPPWQ QQQQQPPPPP PPSSSMASST PLPWQQNTTT TTTSAGTGSI PPWQQQQAAA AASPGAPQMQ GNPTMVPLPP GVQPPLPPGA PPPPPPPPPG SAGMMYAPPP PPPPPMDPSN FVTMMGMGVA GMPPFGMPPA PPPPPPQN . It is sometimes possible for the material contained within the vial of "Splicing factor 1 (SF1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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