Onalespib (AT13387), Inhibitor

Onalespib (AT13387)

Cat. Num. AAA384248

• Purity: >98%
• Synonyms: Onalespib (AT13387); AT-13387; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 24.42 mL (1 mg); 122.1 mL (5 mg); 244.2mL (10 mg); 0.5 mM: 4.88 mL (1 mg); 24.42 mL (5 mg); 48.84 mL (10 mg); 1 mM: 2.44 mL (1 mg); 12.21 mL (5 mg); 24.42 mL (10 mg); 5 mM: 0.49 mL (1 mg); 2.44 mL (5 mg); 4.88 mL (10 mg) (varies by lot)

• CAS Number: 912999-49-6
• Formula: C24H31N3O3
• SMILES: CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
• Actions: Inhibitor
• In Vivo Solvent: 15% Captisol
• Solubility (DMSO): 25 mg/mL (61.04 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (in vivo): 30 mg/mL
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for Onalespib (AT13387), inhibitor

AT13387 is a targeted inhibitor of Hsp90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

References

Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113