SERTA Domain Containing 1 Recombinant Protein | SERTAD1 recombinant protein

Recombinant Human SERTA Domain Containing 1

Cat. Num. AAA144979

• Gene Names: SERTAD1; SEI1; TRIP-Br1
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: SERTA Domain Containing 1; Recombinant Human SERTA Domain Containing 1; SERTAD1 Human; SERTA Domain Containing 1 Human Recombinant; SERTA domain-containing protein 1; CDK4-binding protein p34SEI1; SEI-1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1; SERTAD1; SEI1; SERTAD1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: SERTAD1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 1mM DTT.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMLSKGL KRKREEEEEK EPLAVDSWWL DPGHTAVAQA PPAVASSSLF DLSVLKLHHS LQQSEPDLRH LVLVVNTLRR IQASMAPAAA LPPVPSPPAA PSVADNLLAS SDAALSASMA SLLEDLSHIE GLSQAPQPLA DEGPPGRSIG GAAPSLGALD LLGPATGCLL DDGLEGLFED IDTSMYDNEL WAPASEGLKP GPEDGPGKEE APELDEAELD YLMDVLVGTQ ALERPPGPGR.
• Sequence Length: 236

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for SERTAD1 recombinant protein

Description: SERTAD1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 260 amino acids (1-236 a.a) and having a molecular mass of 27.3kDa (Molecular weight on SDS-PAGE will appear higher).SERTAD1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: SERTA domain-containing protein (SERTAD1) functions with E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. SERTAD1 stimulates E2F-1/DP-1 transcriptional activity. SERTAD1 reduces the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). In addition, SERTAD1 interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Furthermore, SERTAD1 binds to DP1 and interacts with CDK4.

Product Categories/Family for SERTAD1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 153792060
• NCBI GeneID: 29950
• NCBI Accession #: NP_037508.2
• NCBI GenBank Nucleotide #: NM_013376.3
• UniProt Accession #: Q9UHV2; Q9BUE7
• Molecular Weight: 24,704 Da
• NCBI Official Full Name: SERTA domain-containing protein 1
• NCBI Official Synonym Full Names: SERTA domain containing 1
• NCBI Official Symbol: SERTAD1
• NCBI Official Synonym Symbols: SEI1; TRIP-Br1
• NCBI Protein Information: SERTA domain-containing protein 1; CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; SEI-1; transcriptional regulator interacting with the PHD-bromodomain 1
• UniProt Protein Name: SERTA domain-containing protein 1
• Protein Family: SERTA domain-containing protein
• UniProt Gene Name: SERTAD1
• UniProt Synonym Gene Names: SEI1; SEI-1; TRIP-Br1
• UniProt Entry Name: SRTD1_HUMAN

Uniprot Description

SERTAD1: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).

Protein type: Cell cycle regulation; Transcription regulation

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Molecular Function: protein binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity