Complement 1 Inhibitor (C1INH) Recombinant Protein | C1INH recombinant protein

Recombinant Complement 1 Inhibitor (C1INH)

Cat. Num. AAA2009902

• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Complement 1 Inhibitor (C1INH); Recombinant Complement 1 Inhibitor (C1INH); C1INH recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and S-tag, its sequence is listed below.; MHHHHHHSSGLVPRGSGMKETAAAKFERQHMDSPDLGTDDDDKAMADIGS-KVKSS QDMLSIMEKL EFFDFTYDLN LCGLTEDPDL QVSSMKHETV LELTETGVEA AAASTISVAR NLLIFE
• Sequence Length: 504

• Applicable Applications for C1INH recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Rattus norvegicus (Rat)
• Expression System: Prokaryotic expression
• Residues: Lys406~Glu476 (Accession # Q6P734) with two N-terminal Tags, His-tag and S-tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

NCBI and Uniprot Product Information

• NCBI GI #: 40018558
• NCBI GeneID: 295703
• NCBI Accession #: NP_954524.1
• NCBI GenBank Nucleotide #: NM_199093.1
• UniProt Accession #: Q6P734
• Molecular Weight: 13.3kDa
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
• NCBI Official Symbol: Serping1
• NCBI Protein Information: plasma protease C1 inhibitor; C1Inh; C1 Inh; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; serpin peptidase inhibitor, clade G, member 1; serine (or cysteine) peptidase inhibitor, clade G, member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
• UniProt Protein Name: Plasma protease C1 inhibitor
• UniProt Gene Name: Serping1
• UniProt Synonym Gene Names: C1 Inh; C1Inh
• UniProt Entry Name: IC1_RAT

NCBI Description

human homolog acts as a serine protease inhibitor; involved in regulation of the classical complement pathway [RGD, Feb 2006]

Uniprot Description

Function: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein

By similarity.

Subunit structure: Interacts with MASP1

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the serpin family.