Serpin E2/PN1 Recombinant Protein | Serpine2 recombinant protein
Recombinant Mouse Serpin E2/PN1 Protein (C-His)
Background: Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.
NCBI and Uniprot Product Information
Actual Protein Molecular Mass: 50-55kDa
Uniprot Description
SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; extracellular space; extrinsic to external side of plasma membrane; cell soma; membrane; cell; extracellular region; cytosol; neuromuscular junction; vesicle
Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; glycosaminoglycan binding; protease inhibitor activity; receptor binding
Biological Process: negative regulation of proteolysis; nervous system development; regulation of synaptic transmission, glutamatergic; secretory granule organization and biogenesis; multicellular organismal development; cerebellar granular layer morphogenesis; negative regulation of peptidase activity; negative regulation of blood coagulation; detection of mechanical stimulus involved in sensory perception; mating plug formation; negative regulation of cell proliferation; negative regulation of smoothened signaling pathway; response to wounding; negative regulation of cell growth; blood coagulation; negative regulation of protein catabolic process; cell differentiation; regulation of timing of cell differentiation; positive regulation of astrocyte differentiation; negative regulation of phosphoinositide 3-kinase cascade; secretion by cell
Research Articles on Serpine2
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Product Notes
The Serpine2 serpine2 (Catalog #AAA2557500) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Ser20-Pro3 97. It is sometimes possible for the material contained within the vial of "Serpin E2/PN1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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