Heparin cofactor 2 (SERPIND1) Recombinant Protein | SERPIND1 recombinant protein
Recombinant Human Heparin cofactor 2 (SERPIND1)
Gene Names
SERPIND1; HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Heparin cofactor 2 (SERPIND1); Recombinant Human Heparin cofactor 2 (SERPIND1); SERPIND1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
20-499, Full length protein
Sequence
GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS
Sequence Length
480
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for SERPIND1 recombinant protein
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,071 Da
NCBI Official Full Name
heparin cofactor 2
NCBI Official Synonym Full Names
serpin family D member 1
NCBI Official Symbol
SERPIND1
NCBI Official Synonym Symbols
HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
NCBI Protein Information
heparin cofactor 2
UniProt Protein Name
Heparin cofactor 2
Protein Family
UniProt Gene Name
SERPIND1
UniProt Synonym Gene Names
HCF2; HC-II; HLS2
NCBI Description
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Uniprot Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Research Articles on SERPIND1
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Product Notes
The SERPIND1 serpind1 (Catalog #AAA948892) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-499, Full length protein. The amino acid sequence is listed below: GSKGPLDQLE KGGETAQSAD PQWEQLNNKN LSMPLLPADF HKENTVTNDW IPEGEEDDDY LDLEKIFSED DDYIDIVDSL SVSPTDSDVS AGNILQLFHG KSRIQRLNIL NAKFAFNLYR VLKDQVNTFD NIFIAPVGIS TAMGMISLGL KGETHEQVHS ILHFKDFVNA SSKYEITTIH NLFRKLTHRL FRRNFGYTLR SVNDLYIQKQ FPILLDFKTK VREYYFAEAQ IADFSDPAFI SKTNNHIMKL TKGLIKDALE NIDPATQMMI LNCIYFKGSW VNKFPVEMTH NHNFRLNERE VVKVSMMQTK GNFLAANDQE LDCDILQLEY VGGISMLIVV PHKMSGMKTL EAQLTPRVVE RWQKSMTNRT REVLLPKFKL EKNYNLVESL KLMGIRMLFD KNGNMAGISD QRIAIDLFKH QGTITVNEEG TQATTVTTVG FMPLSTQVRF TVDRPFLFLI YEHRTSCLLF MGRVANPSRS. It is sometimes possible for the material contained within the vial of "Heparin cofactor 2 (SERPIND1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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