SERPINB6 recombinant protein

Recombinant Human SERPINB6 Protein

Cat. Num. AAA8249772

• Gene Names: SERPINB6; CAP; PI6; PTI; PI-6; SPI3; DFNB91; MSTP057
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: SERPINB6; Recombinant Human SERPINB6 Protein; PI6; PTI; Serpin B6; Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor; SERPINB6 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence: MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL KEFLDANLAG SGSGHMHHHH HHSSGLVPRG SGMKETAAAK FERQHMDSPD LGTDDDDKAM ADIGSEFHMD VLAEANGTFA LNLLKTLGKD NSKNVFFSPM SMSCALAMVY MGAKGNTAAQ MAQILSFNKS GGGGDIHQGF QSLLTEVNKT GTQYLLRVAN RLFGEKSCDF LSSFRDSCQK FYQAEMEELD FISAVEKSRK HINTWVAEKT EGKIAELLSP GSVDPLTRLV LVNAVYFRGN WDEQFDKENT EERLFKVSKN EEKPVQMMFK QSTFKKTYIG EIFTQILVLP YVGKELNMII MLPDETTDLR TVEKELTYEK FVEWTRLDMM DEEEVEVSLP RFKLEESYDM ESVLRNLGMT DAFELGKADF SGMSQTDLSL SKVVHKSFVE VNEEGTEAAA ATAAIMMMRC ARFVPRFCAD HPFLFFIQHS KTNGILFCGR FSSP
• Sequence Length: 380

• Applicable Applications for SERPINB6 recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for SERPINB6 recombinant protein

Recombinant Human SERPINB6 Protein is produced by our E Coli expression system and the target gene encoding Met1-Pro376 is expressed with a Trx, 6His tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 425876796
• NCBI GeneID: 5269
• NCBI Accession #: NP_001182220.2
• NCBI GenBank Nucleotide #: NM_001195291.2
• UniProt Accession #: P35237; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7; B2RBA8
• Molecular Weight: 42,622 Da
• NCBI Official Full Name: serpin B6 isoform b
• NCBI Official Synonym Full Names: serpin family B member 6
• NCBI Official Symbol: SERPINB6
• NCBI Official Synonym Symbols: CAP; PI6; PTI; PI-6; SPI3; DFNB91; MSTP057
• NCBI Protein Information: serpin B6
• UniProt Protein Name: Serpin B6
• Protein Family: Serpin
• UniProt Gene Name: SERPINB6
• UniProt Synonym Gene Names: PI6; PTI; CAP; PI-6
• UniProt Entry Name: SPB6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

SERPINB6: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91). It is a form of non- syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: cytoplasm; cytosol; extracellular space; nucleus; protein complex

Molecular Function: protease binding; serine-type endopeptidase inhibitor activity

Biological Process: sensory perception of sound

Disease: Deafness, Autosomal Recessive 91