SerpinA7 / TBG Recombinant Protein | TBG recombinant protein
Recombinant Mouse SerpinA7 / TBG Protein (His tag)
Gene Names
Serpina7; Tbg; C730040N12Rik
Purity
> 97 % as determined by SDS-PAGE
Synonyms
SerpinA7 / TBG; Recombinant Mouse SerpinA7 / TBG Protein (His tag); RP23-228A20.1; C730040N12Rik; Tbg; Serpina7; TBG recombinant protein
Host
Human Cells
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
426
Application Notes
The secreted recombinant mouse SERPINA7comprises 409 amino acids and has a predicted molecular mass of 46.2 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
Predicted N Terminal
Ala 21
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
Related Product Information for TBG recombinant protein
Background: Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver as a 54 kDa protein.TBG is genomically a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.
Description: A DNA sequence encoding the mouse SERPINA7 (NP_808588.3) (Met 1-Gln 418) was fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the mouse SERPINA7 (NP_808588.3) (Met 1-Gln 418) was fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,052 Da
NCBI Official Full Name
thyroxine-binding globulin
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
NCBI Official Symbol
Serpina7
NCBI Official Synonym Symbols
Tbg; C730040N12Rik
NCBI Protein Information
thyroxine-binding globulin
UniProt Protein Name
Thyroxine-binding globulin
UniProt Gene Name
Serpina7
UniProt Synonym Gene Names
Tbg
Uniprot Description
SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: X|X F1
Cellular Component: extracellular space
Molecular Function: hormone binding; serine-type endopeptidase inhibitor activity
Biological Process: post-embryonic development; response to drug; response to vitamin A
Research Articles on TBG
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Product Notes
The TBG serpina7 (Catalog #AAA2547044) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse SERPINA7comprises 409 amino acids and has a predicted molecular mass of 46.2 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TBG serpina7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinA7 / TBG, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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