Serpin A1a Recombinant Protein | SERPINA1A recombinant protein

Recombinant Mouse Serpin A1a Protein

Cat. Num. AAA8305330

• Gene Names: Serpina1a; PI1; Aat2; Dom1; Aat-2; Spi1-1; Spi1-3
• Applications: ELISA, Western Blot, SDS-Page
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Serpin A1a; Recombinant Mouse Serpin A1a Protein; Alpha-1-antitrypsin 1-1; AAT; Alpha-1 protease inhibitor 1; Alpha-1-antiproteinase; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; Serpina1a; Dom1; Spi1-1; SERPINA1A recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Liquid in a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
• Sequence: EDVQETDTSQ KDQSPASHEI ATNLGDFAIS LYRELVHQSN TSNIFFSPVS IATAFAMLSL GSKGDTHTQI LEGLQFNLTQ TSEADIHNSF QHLLQTLNRP DSELQLSTGN GLFVNNDLKL VEKFLEEAKN HYQAEVFSVN FAESEEAKKV INDFVEKGTQ GKIVEAVKKL EQDTVFVLAN YILFKGKWKK PFDPENTKQA EFHVDESTTV KVPMMTLSGM LDVHHCSTLS SWVLLMDYAG NATAVFLLPD DGKMQHLEQT LNKELISKFL LNRRRRLAQI HIPRLSISGN YNLETLMSPL GITRIFNSGA DLSGITEENA PLKLSQAVHK AVLTIDETGT EAAAATVLQG GFLSMPPILH FNRPFLFIIF EEHSQSPLFV GKVVDPTHKV DHHHHHH
• Sequence Length: 413

• Applicable Applications for SERPINA1A recombinant protein: ELISA (EIA), Western Blot (WB), SDS-PAGE
• Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
• Preparation and Storage: Store it at -20 degree C to -80 degree C for one year. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Related Product Information for SERPINA1A recombinant protein

Recombinant Mouse Serpin A1a Protein is produced by mammalian expression system and the target gene encoding Glu25-Lys413 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 6678079
• NCBI GeneID: 20700
• NCBI Accession #: NP_033269.1
• NCBI GenBank Nucleotide #: NP_033269.1
• UniProt Accession #: P07758
• NCBI Official Full Name: alpha-1-antitrypsin 1-1 isoform 1
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade A, member 1A
• NCBI Official Symbol: Serpina1a
• NCBI Official Synonym Symbols: PI1; Aat2; Dom1; Aat-2; Spi1-1; Spi1-3
• NCBI Protein Information: alpha-1-antitrypsin 1-1
• UniProt Protein Name: Alpha-1-antitrypsin 1-1
• Protein Family: Alpha-1-antitrypsin
• UniProt Gene Name: Serpina1a
• UniProt Synonym Gene Names: Dom1; Spi1-1; AAT; Serpin A1a

Uniprot Description

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12 E|12 52.98 cM

Cellular Component: endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: protein amino acid N-linked glycosylation; response to cytokine stimulus; response to peptide hormone stimulus