Alpha-1-antiproteinase (Serpina1) Recombinant Protein | Serpina1 recombinant protein

Recombinant Rat Alpha-1-antiproteinase (Serpina1)

Cat. Num. AAA9423270

• Gene Names: Serpina1; Pi; AAT; Spi1
• Reactivity: Rat
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Alpha-1-antiproteinase (Serpina1); Recombinant Rat Alpha-1-antiproteinase (Serpina1); Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; Serpina1; Serpina1 recombinant protein

• Host: E Coli
• Reactivity: Rat
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Full Length, 25-411aa

• Tag Info: N-terminal 6xHis-SUMO-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

Related Product Information for Serpina1 recombinant protein

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

NCBI and Uniprot Product Information

• NCBI GI #: 51036655
• NCBI GeneID: 24648
• NCBI Accession #: NP_071964.2
• NCBI GenBank Nucleotide #: NM_022519.2
• UniProt Accession #: P17475; Q6AYZ5
• Molecular Weight: 31.63 kDa
• NCBI Official Full Name: alpha-1-antiproteinase
• NCBI Official Synonym Full Names: serpin family A member 1
• NCBI Official Symbol: Serpina1
• NCBI Official Synonym Symbols: Pi; AAT; Spi1
• NCBI Protein Information: alpha-1-antiproteinase
• UniProt Protein Name: Alpha-1-antiproteinase
• Protein Family: Alpha-1-antitrypsin
• UniProt Gene Name: Serpina1

Uniprot Description

SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q32

Cellular Component: endoplasmic reticulum; extracellular space; Golgi apparatus; intracellular membrane-bound organelle

Molecular Function: endopeptidase inhibitor activity; glycoprotein binding; identical protein binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: inflammatory response; response to chromate; response to cytokine stimulus; response to estradiol stimulus; response to hypoxia; response to inorganic substance; response to lead ion; response to lipopolysaccharide; response to methanol; response to organic cyclic substance; response to triglyceride