SEPT6 / Septin-6 Recombinant Protein | SEPT6 recombinant protein

Human SEPT6 / Septin-6 Recombinant Protein

• Gene Names: SEPTIN6; SEP2; SEPT2; SEPT6
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: SEPT6 / Septin-6; Human SEPT6 / Septin-6 Recombinant Protein; Septin-6; KIAA0128; SEP2; SEPT6 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 434

• Applicable Applications for SEPT6 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.
• Entry Function: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 21361478
• NCBI GeneID: 23157
• NCBI Accession #: NP_055944.2
• NCBI GenBank Nucleotide #: NP_055944.2
• UniProt Accession #: Q14141
• NCBI Official Full Name: septin-6 isoform B
• NCBI Official Synonym Full Names: septin 6
• NCBI Official Symbol: SEPTIN6
• NCBI Official Synonym Symbols: SEP2; SEPT2; SEPT6
• NCBI Protein Information: septin-6
• UniProt Protein Name: Septin-6
• UniProt Gene Name: SEPT6
• UniProt Synonym Gene Names: KIAA0128; SEP2
• UniProt Entry Name: SEPT6_HUMAN

NCBI Description

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

SEPT6: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Belongs to the septin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cytoskeletal

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: synaptic vesicle; spindle; midbody; nerve terminal; cleavage furrow

Molecular Function: protein binding; GTP binding

Biological Process: viral reproduction; cytokinesis