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6 results for "a K ATPase inhibitor" - showing 1-6
Testing Data
(PF-03716556 is a potent, and selective acid pump antagonist with pIC50 of 6.026 +/- 0.112, 6.038 +/- 0.039 and 6.009 +/- 0.209 at pH 6.4 for the inhibition of H+, K+-ATPase activity of porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 is used for the treatment of gastroesophageal reflux disease. PF-03716556 is highly selective for H+, K+-ATPase in vitro. PF-03716556 displays no activity at Na+, K+-ATPase. PF-03716556 inhibits gastric acid secretion in rat and dog models. PF-03716556 has no species differences among the porcine, canine and human enzymes. PF-03716556 produced greater inhibition than revaprazan in both the in vitro (ion-tight assay) and in vivo conditions. PF-03716556 offers long-lasting and maximal efficacy within 30 min of a single dosing with responses that are maintained for at least 5 days of repeated dosing with no signs of tolerance. PF-03716556 did not exhibit any biologically relevant activity against any of the tested more than 50 (e.g., adenosine receptor) receptors, ion channels, or enzymes expressed in na¯ve tissues, cell lines and transfectants. [1])
PF 3716556, Inhibitor (Cat# AAA8506512)
Full Name
PF 3716556
Purity
>99%
Pricing
$410/10 mg | $1,795/5x10 mg
YCHF, Polyclonal Antibody (Cat# AAA7165778)
Full Name
Rabbit anti-Escherichia coli (strain K12) YCHF Polyclonal Antibody
Gene Names
ychF; ECK1191; engD; gtp1; JW1194
Reactivity
E Coli (strain K12)
Applications
EIA, Western Blot, ensure identification of antigen
Purity
Protein A/G
Chemical Structure
Ouabain, Inhibitor (Cat# AAA387409)
Full Name
Ouabain
Purity
>98%
Pricing
$160/250 mg | $230/500 mg | $340/1 g | $570/2 g | $140/1 mL (in DMSO) | $2,515/5x2 g
Structure
Deslanoside, Inhibitor (Cat# AAA5759004)
Full Name
Deslanoside
Purity
98.00%
Pricing
$325/5 mg | $445/10 mg | $1,725/5x10 mg
Structure
DMP 777, Inhibitor (Cat# AAA5754797)
Full Name
DMP 777
Purity
98.00%
Pricing
$310/5 mg | $380/10 mg | $565/25 mg | $825/50 mg | $1,270/100 mg | $345/1mL*10mM (in DMSO) | $5,430/5x100 mg
Chemical Structure
Tegoprazan, Inhibitor (Cat# AAA5764700)
Full Name
Tegoprazan
Purity
0.9822
Pricing
$255/1 mg | $360/5 mg | $500/10 mg | $865/25 mg | $1,255/50 mg | $1,880/100 mg | $8,190/5x100 mg
