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4 results for "Cdc7 kinase inhibitor" - showing 1-4
Testing Data
(Published customer image: Confirmation and in vitro characterization of Hit compounds. A) HeLa cells were treated with the ten compounds that produced the strongest reduction in pSer40/41MCM2 levels in the primary screen. Protein extracts were prepared and levels of residual pSer40/41MCM2 phosphorylation were measured by western blot analysis with the indicated antibodies. B) The same compounds were tested for their ability to inhibit CDC7 kinase activity in in vitro kinase assay. Kinase reactions were performed on a synthetic MCM2 substrate in the absence or presence of the indicated drug and reactions were run on SDS-PAGE gels. CDC7 activity on the synthetic MCM2 substrate was monitored by Western blotting with an anti-pSer108MCM2 antibody. As a control the levels of CDC7 kinase and synthetic MCM2 substrate present in each reaction were also assessed and shown to be similar in all reactions.From: FitzGerald J, Murillo LS, O'Brien G, O'Connell E, O'Connor A, et al. (2014) A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response. PLoS ONE 9(6): e98891.)
MCM2, Monoclonal Antibody (Cat# AAA212357)
Full Name
MOUSE ANTI HUMAN MCM2
Gene Names
MCM2; BM28; CCNL1; CDCL1; cdc19; D3S3194; MITOTIN
Applications
WB
Pricing
$345/0.1 mg | $1,405/5x0.1 mg
XL413, Inhibitor (Cat# AAA578386)
Full Name
XL413
Purity
98.0%
Pricing
$285/5 mg | $335/10 mg | $530/25 mg | $730/50 mg | $3,010/5x50 mg
(R)-Simurosertib, Inhibitor (Cat# AAA3846317)
Full Name
(R)-Simurosertib
Purity
>98%
Pricing
$195/2 mg | $320/5 mg | $580/10 mg | $1,595/50 mg | $7,120/5x50 mg
Chemical Structure
Cdc7-IN-1, Inhibitor (Cat# AAA387265)
Full Name
Cdc7-IN-1
Purity
>98%
Pricing
$385/5 mg | $625/10 mg | $1,745/50 mg | $3,430/100 mg
