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5 results for "ATP competitive AKT inhibitor" - showing 1-5
Testing Data
(GSK690693 is an aminofurazan-derived, novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor. It is selective for the Akt isoforms(inhibits Akt kinases 1, 2, and 3 with IC50 values of 2, 13, and 9 nM respectively)versus the majority of kinases in other families; however, it does inhibit additional members of the AGC kinase family. [1,2]GSK690693 inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of Akt kinase activity. [1]Daily administration of GSK690693 produced significant antitumor activity in mice bearing established human SKOV-3 ovarian, LNCaP prostate, and BT474 and HCC-1954 breast carcinoma xenografts. [1])
GSK690693, Inhibitor (Cat# AAA8506383)
Full Name
GSK690693
Purity
>99%
Pricing
$1,535/10 mg | $6,870/5x10 mg
Testing Data
(PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110alpha, mTORC1, PI3-KC2beta, p110delta, mTORC2, p110beta, and p110gamma, respectively. It shows little activity against a wide array of protein kinases at 10 mM. It blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. PI-103 was essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibited leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 had additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [1][2][3])
Acacetin, Inhibitor (Cat# AAA579895)
Full Name
Acacetin
Purity
96.3%
Pricing
$195/5 mg | $205/10 mg | $230/25 mg | $195/1 mL (in DMSO) | $760/5x25 mg
PHA767491, Inhibitor (Cat# AAA5750152)
Full Name
PHA767491 HCl
Purity
98.00%
Pricing
$195/5 mg | $210/10 mg | $250/25 mg | $510/100 mg | $195/1 mL (in DMSO) | $2,030/5x100 mg
Solenopsin, Inhibitor (Cat# AAA3845519)
Full Name
Solenopsin
Purity
>98%
Pricing
$420/1 mg | $1,155/5 mg | $1,900/10 mg | $8,485/5x10 mg
