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19 results for " FMK Inhibitors" - showing 1-19
Testing Data
(Published customer image: Confirmation and in vitro characterization of Hit compounds. A) HeLa cells were treated with the ten compounds that produced the strongest reduction in pSer40/41MCM2 levels in the primary screen. Protein extracts were prepared and levels of residual pSer40/41MCM2 phosphorylation were measured by western blot analysis with the indicated antibodies. B) The same compounds were tested for their ability to inhibit CDC7 kinase activity in in vitro kinase assay. Kinase reactions were performed on a synthetic MCM2 substrate in the absence or presence of the indicated drug and reactions were run on SDS-PAGE gels. CDC7 activity on the synthetic MCM2 substrate was monitored by Western blotting with an anti-pSer108MCM2 antibody. As a control the levels of CDC7 kinase and synthetic MCM2 substrate present in each reaction were also assessed and shown to be similar in all reactions.From: FitzGerald J, Murillo LS, O'Brien G, O'Connell E, O'Connor A, et al. (2014) A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response. PLoS ONE 9(6): e98891.)
MCM2, Monoclonal Antibody (Cat# AAA212357)
Full Name
MOUSE ANTI HUMAN MCM2
Gene Names
MCM2; BM28; CCNL1; CDCL1; cdc19; D3S3194; MITOTIN
Applications
WB
Pricing
$345/0.1 mg | $1,405/5x0.1 mg
Caspase 2 Inhibitor, Cell Culture, VDVAD-FMK, 2mM, Inhibitor (Cat# AAA655466)
Full Name
Caspase 2 Inhibitor, Cell Culture, VDVAD-FMK, 2mM (ICH1, Nedd2)
Purity
Highly Purified
98% by HPLC analysis
98% by HPLC analysis
Pricing
$410/0.1 mL | $1,845/5x0.1 mL
Caspase 10 Inhibitor, Cell Culture, 2mM, Z-AEVD-FMK, Inhibitor (Cat# AAA655333)
Full Name
Caspase 10 Inhibitor, Cell Culture, 2mM, Z-AEVD-FMK (FLICE2, Mch4)
Purity
Highly Purified
95% by HPLC analysis
95% by HPLC analysis
Pricing
$410/0.1 mL | $1,845/5x0.1 mL
Calpain Inhibitor, Z-LLY-FMK, Inhibitor (Cat# AAA655321)
Full Name
Calpain Inhibitor, Z-LLY-FMK
Purity
Molecular Biology Grade
95% by HPLC analysis
95% by HPLC analysis
Pricing
$410/0.02 mL | $1,845/5x0.02 mL
Z-VAD (OMe), Inhibitor (Cat# AAA669121)
Full Name
Z-VAD (OMe)-FMK
Applications
Functional Assay
Purity
HPLC > 90 %
Pricing
$750/5 mg | $3,320/5x5 mg
Z-D(OMe)E(OMe)VD(OMe), Inhibitor (Cat# AAA669123)
Full Name
Z-D(OMe)E(OMe)VD(OMe)-FMK (Caspase 3, 7 Inhibitor)
Applications
Functional Assay
Pricing
$980/5 mg | $4,365/5x5 mg
Z-LE(OMe)HD(OMe), Inhibitor (Cat# AAA669125)
Full Name
Z-LE(OMe)HD(OMe)-FMK (Caspase 9 Inhibitor)
Applications
Functional Assay
Pricing
$865/5 mg | $3,845/5x5 mg
Z-IE(OMe)TD(OMe), Inhibitor (Cat# AAA669124)
Full Name
Z-IE(OMe)TD(OMe)-FMK (Caspase 8 Inhibitor)
Applications
Functional Assay
Pricing
$980/5 mg | $4,365/5x5 mg
Z-VAD (OMe)-FMK, Peptide (Cat# AAA566487)
Full Name
Z-VAD (OMe)-FMK
Purity
>=95%
Pricing
$260/1 mg | $1,135/5x1 mg
Z-YVAD (OMe)-FMK, Peptide (Cat# AAA566169)
Full Name
Z-YVAD (OMe)-FMK [Caspase-1 Inhibitor (FMK)]
Purity
>=98% (TLC)
Pricing
$555/1 mg | $2,435/5x1 mg
Z-VRPR-FMK, Peptide (Cat# AAA566185)
Full Name
Z-VRPR-FMK
Purity
>=90% (HPLC)
Pricing
$735/1 mg | $3,255/5x1 mg
Z-Phe-Ala-FMK, Peptide (Cat# AAA566512)
Full Name
Z-Phe-Ala-FMK
Purity
>=95% (HPLC)
Pricing
$240/1 mg | $705/5 mg | $3,135/5x5 mg
Boc-D, Peptide (Cat# AAA566166)
Full Name
Boc-D (OMe)-FMK [Pan-Caspase Specific Inhibitor (FMK)]
Purity
>=95% (TLC)
Pricing
$400/1 mg | $1,755/5x1 mg
Z-IE (OMe)TD (OMe)-FMK, Peptide (Cat# AAA566168)
Full Name
Z-IE (OMe)TD (OMe)-FMK [Caspase-8/Caspase-3 Proc.Enzyme/Granzyme B (FMK)]
Purity
>=95% (TLC)
Pricing
$390/1 mg | $1,700/5x1 mg
Z-VAD-FMK, Peptide (Cat# AAA566145)
Full Name
Z-VAD-FMK [Pan-Caspase Specific Inhibitor (FMK)]
Purity
>=98% (HPLC)
Pricing
$240/1 mg | $680/5 mg | $3,010/5x5 mg
Z-D (OMe)E (OMe)VD (OMe)-FMK, Peptide (Cat# AAA566167)
Full Name
Z-D (OMe)E (OMe)VD (OMe)-FMK [Caspase-3/Caspase-7 Inhibitor (FMK)]
Purity
>=95% (TLC)
Pricing
$1,375/5 mg | $6,140/5x5 mg
Z-VEID-FMK, Inhibitor (Cat# AAA5758008)
Full Name
Z-VEID-FMK
Purity
98.00%
Pricing
$245/1 mg | $395/5 mg | $580/10 mg | $850/25 mg | $3,525/5x25 mg
Z-LE (OMe)HD (OMe)-FMK, Peptide (Cat# AAA566170)
Full Name
Z-LE (OMe)HD (OMe)-FMK [Caspase-9 Inhibitor (FMK)]
Purity
>=95% (HPLC)
Pricing
$410/1 mg | $1,785/5x1 mg
Q-VD(OMe)-OPh, Inhibitor (Cat# AAA5757673)
Full Name
Q-VD(OMe)-OPh
Purity
98.00%
Pricing
$245/1 mg | $395/5 mg | $580/10 mg | $850/25 mg | $645/1mL*10mM (in DMSO) | $3,525/5x25 mg
