Sodium channel modifier 1 (Scnm1) Recombinant Protein | Scnm1 recombinant protein

Recombinant Mouse Sodium channel modifier 1 (Scnm1)

Cat. Num. AAA1310062

• Gene Names: Scnm1; Scnm1-ps; 3110001I17Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sodium channel modifier 1 (Scnm1); Recombinant Mouse Sodium channel modifier 1 (Scnm1); Scnm1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-229, full length protein
• Sequence: MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHRPEAPAPSVSSPPLPTAEVQLQSAEISKEPEPRERSDAKESAALLASAPMSPTKRRVLNHYLTLRSSGWVPDGRGRWIKDENVEFDSDEEEPPDLPLD
• Sequence Length: 229

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 254675275
• NCBI GeneID: 69269
• NCBI Accession #: NP_001157045.1
• NCBI GenBank Nucleotide #: NM_001163573.1
• UniProt Accession #: Q8K136; Q9CXV5
• Molecular Weight: 18,780 Da
• NCBI Official Full Name: sodium channel modifier 1 isoform 2
• NCBI Official Synonym Full Names: sodium channel modifier 1
• NCBI Official Symbol: Scnm1
• NCBI Official Synonym Symbols: Scnm1-ps; 3110001I17Rik
• NCBI Protein Information: sodium channel modifier 1
• UniProt Protein Name: Sodium channel modifier 1
• Protein Family: Sodium channel modifier
• UniProt Gene Name: Scnm1
• UniProt Synonym Gene Names: Scnm1-ps

NCBI Description

Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009]

Uniprot Description

Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites.