SCN3B recombinant protein

SCN3B, 23-159aa, Human, His-tag, Baculovirus

Cat. Num. AAA206527

• Gene Names: SCN3B; SCNB3; ATFB16; BRGDA7; HSA243396
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: SCN3B; 23-159aa; Human; His-tag; Baculovirus; Sodium channel subunit beta-3; ATFB16; BRGDA7; HSA243396; SCNB3; SCN3B recombinant protein

• Host: Baculovirus
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 1mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPFPVCVEV PSETEAVQGN PMKLRCISCM KREEVEATTV VEWFYRPEGG KDFLIYEYRN GHQEVESPFQ GRLQWNGSKD LQDVSITVLN VTLNDSGLYT CNVSREFEFE AHRPFVKTTR LIPLRVTEEA GEDFTSVVSE HHHHHH
• Sequence Length: 215

• Applicable Applications for SCN3B recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for SCN3B recombinant protein

SCN3B, also known as sodium channel subunit beta-3, is an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. It was detected in brain, heart, kidney, lung, pancreas and skeletal muscle. It is expressed in adult mammalian skeletal muscle and can functionally couple to the skeletal muscle alpha subunit, SkM1. It associates with neurofascin through their extracellular immunoglobulin-like domain. Recombinant human SCN3B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for SCN3B recombinant protein

Apoptosis

References

Stevens EB., et al. (2001) Pflugers Arch. 441:481-488.; Ratcliffe CF., et al. (2001) J Cell Biol. 154:427-434.

NCBI and Uniprot Product Information

• NCBI GI #: 9055238
• NCBI GeneID: 55800
• NCBI Accession #: NP_060870
• NCBI GenBank Nucleotide #: NM_018400.3
• UniProt Accession #: Q9NY72; Q17RL3; Q9ULR2; A5H1I5
• Molecular Weight: 16.8kDa (146aa) 18-28kDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: sodium channel subunit beta-3
• NCBI Official Synonym Full Names: sodium voltage-gated channel beta subunit 3
• NCBI Official Symbol: SCN3B
• NCBI Official Synonym Symbols: SCNB3; ATFB16; BRGDA7; HSA243396
• NCBI Protein Information: sodium channel subunit beta-3
• UniProt Protein Name: Sodium channel subunit beta-3
• Protein Family: Sodium channel
• UniProt Gene Name: SCN3B
• UniProt Synonym Gene Names: KIAA1158

NCBI Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons ().