Sodium channel subunit beta-1 Recombinant Protein | Scn1b recombinant protein
Sodium channel subunit beta-1
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
SCN1B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, sodium; Membrane protein, integral
Cellular Component: T-tubule; voltage-gated sodium channel complex
Molecular Function: protein binding; sodium channel inhibitor activity; sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: action potential propagation; axon guidance; cardiac muscle contraction; corticospinal neuron axon guidance; locomotion; membrane depolarization; regulation of sodium ion transport; response to pyrethroid
Research Articles on Scn1b
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Product Notes
The Scn1b scn1b (Catalog #AAA7043269) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-218aa; full length protein. The amino acid sequence is listed below: GGCVEVDSDT EAVYGMTFKI LCISCKRRSE TTAETFTEWT FRQKGTEEFV KILRYENEVL QLEEDERFEG RVVWNGSRGT KDLQDLSIFI TNVTYNHSGD YECHVYRLLF FDNYEHNTSV VKKIHLEVVD KANRDMASIV SEIMMYVLIV VLTIWLVAEM VYCYKKIAAA TEAAAQENAS EYLAITSESK ENCTGVQVAE. It is sometimes possible for the material contained within the vial of "Sodium channel subunit beta-1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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