Scaffold protein salvador (sav) Recombinant Protein | sav recombinant protein

Recombinant Drosophila melanogaster Scaffold protein salvador (sav), partial

• Gene Names: sav; anon-WO0172774.152; CG13831; CG13832; CG33193; DmelCG33193; Salvador/Shar-pei; Sav; shar-pei
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Scaffold protein salvador (sav); Recombinant Drosophila melanogaster Scaffold protein salvador (sav); partial; sav recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 608

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 28572108
• NCBI GeneID: 252554
• NCBI Accession #: NP_788721.1
• NCBI GenBank Nucleotide #: NM_176544.3
• UniProt Accession #: Q9VCR6; Q8MQH6; Q8T9A6; Q9VCR5
• Molecular Weight: 68,146 Da
• NCBI Official Full Name: salvador, isoform A
• NCBI Official Synonym Full Names: salvador
• NCBI Official Symbol: sav
• NCBI Official Synonym Symbols: anon-WO0172774.152; CG13831; CG13832; CG33193; DmelCG33193; Salvador/Shar-pei; Sav; shar-pei
• NCBI Protein Information: CG33193 gene product from transcript CG33193-RB
• UniProt Protein Name: Scaffold protein salvador
• Protein Family: Scaffold protein salvador
• UniProt Gene Name: sav
• UniProt Synonym Gene Names: SHRP

Uniprot Description

Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Required for cell cycle exit in eye imaginal disk and hid-induced apoptotic cell deaths that are part of normal retinal development. Activation of Drice in eye imaginal disk by either Hid or Rpr is almost completely blocked by Sav expression.