SDS-PAGE
Seryl-tRNA synthetase, cytoplasmic Recombinant Protein | SARS recombinant protein
Recombinant human Seryl-tRNA synthetase, cytoplasmic
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]
Uniprot Description
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Ref.1
Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
Subunit structure: Homodimer. The tRNA molecule binds across the dimer
By similarity.
Subcellular location: Cytoplasm.
Domain: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding
By similarity.
Post-translational modification: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7
Sequence similarities: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
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Product Notes
The SARS sars (Catalog #AAA717199) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-233. Partial. The amino acid sequence is listed below: VLDLDLFRVD KGGDPALIRE TQEKRFKDPG LVDQLVKADS EWRRCRFRAD NLNKLKNLCS KTIGEKMKKK EPVGDDESVP ENVLSFDDLT ADALANLKVS QIKKVRLLID EAILKCDAER IKLEAERFEN LREIGNLLHP SVPISNDEDV DNKVERIWGD CTVRKKYSHV DLVVMVDGFE GEKGAVVAGS RGYFLKGVLV FLEQALIQYA LRTLGSRGYI PIYTPFFMRK EV . It is sometimes possible for the material contained within the vial of "Seryl-tRNA synthetase, cytoplasmic, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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