Human sal-like 1 (Drosophila) ELISA Kit | SALL1 elisa kit

Human Sal-like protein 1, SALL1 ELISA Kit

Cat. Num. AAA9324263

• Gene Names: SALL1; TBS; HSAL1; Sal-1; ZNF794; HEL-S-89
• Reactivity: Human
• Synonyms: sal-like 1 (Drosophila); Human Sal-like protein 1; SALL1 ELISA Kit; Human Sal-like protein 1 (SALL1) ELISA kit; HSAL1; TBS; ZNF794; sal-like 1; spalt-like transcription factor 1; SALL1 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: undiluted original Human body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/mL
• Sensitivity: 0.1ng/mL
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for SALL1 elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of SALL1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 189217876
• NCBI GeneID: 6299
• NCBI Accession #: NP_001121364.1
• NCBI GenBank Nucleotide #: NM_001127892.1
• UniProt Accession #: Q9NSC2; Q99881; Q9NSC3; Q9P1R0
• Molecular Weight: 140,405 Da
• NCBI Official Full Name: sal-like protein 1 isoform b
• NCBI Official Synonym Full Names: spalt-like transcription factor 1
• NCBI Official Symbol: SALL1
• NCBI Official Synonym Symbols: TBS; HSAL1; Sal-1; ZNF794; HEL-S-89
• NCBI Protein Information: sal-like protein 1; zinc finger protein 794; zinc finger protein SALL1; zinc finger protein Spalt-1; epididymis secretory protein Li 89
• UniProt Protein Name: Sal-like protein 1
• Protein Family: Sal-like protein
• UniProt Gene Name: SALL1
• UniProt Synonym Gene Names: SAL1; ZNF794; HSal1; Sal-1
• UniProt Entry Name: SALL1_HUMAN

NCBI Description

The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SALL1: Transcriptional repressor involved in organogenesis. Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS). TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss. Some individuals with SALL1 mutations manifest a phenotype overlapping with TBS and bronchio-oto-renal syndrome. Clinical features include dysplastic ears, hypoplastic kidneys with impaired renal function, gastroesophageal reflux, hypermetropia, hypospadias, and mild developmental delay. Affected individuals lack the characteristic anal or hand malformations of TBS. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: heterochromatin; cytoplasm; NuRD complex; nucleus; chromocenter

Molecular Function: protein binding; DNA binding; metal ion binding; beta-catenin binding; chromatin binding; histone deacetylase activity; transcription factor activity

Biological Process: limb development; hindlimb morphogenesis; gonad development; heart development; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; olfactory nerve development; forelimb morphogenesis; inductive cell-cell signaling; ureteric bud development; kidney development; embryonic gut development; positive regulation of Wnt receptor signaling pathway; transcription, DNA-dependent; adrenal gland development; outer ear morphogenesis; histone deacetylation; pituitary gland development; ureteric bud branching; negative regulation of smoothened signaling pathway; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation

Disease: Townes-brocks Syndrome