Sphingosine 1-phosphate receptor 1 (S1pr1) Recombinant Protein | S1pr1 recombinant protein
Recombinant Rat Sphingosine 1-phosphate receptor 1 (S1pr1)
NCBI and Uniprot Product Information
NCBI Description
G-protein-coupled receptor homolog; may mediate neurotransmission and endothelial cell differentiation [RGD, Feb 2006]
Uniprot Description
EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Cellular Component: integral to membrane; intrinsic to plasma membrane; endosome; lipid raft; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; sphingolipid binding; G-protein-coupled receptor binding
Biological Process: lamellipodium biogenesis; regulation of cell adhesion; endothelial cell differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); cell migration; regulation of bone resorption; negative regulation of stress fiber formation; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; transmission of nerve impulse; chemotaxis; blood vessel maturation; neuron differentiation; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; actin cytoskeleton reorganization; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; brain development; regulation of bone mineralization; positive regulation of cell migration; positive regulation of GTPase activity
Research Articles on S1pr1
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Product Notes
The S1pr1 s1pr1 (Catalog #AAA949854) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-383. The amino acid sequence is listed below: MVSSTSIPVV KALRSQVSDY GNYDIIVRHY NYTGKLNIGV EKDHGIKLTS VVFILICCLI ILENIFVLLT IWKTKKFHRP MYYFIGNLAL SDLLAGVAYT ANLLLSGATT YKLTPAQWFL REGSMFVALS ASVFSLLAIA IERYITMLKM KLHNGSNSSR SFLLISACWV ISLILGGLPI MGWNCISSLS SCSTVLPLYH KHYILFCTTV FTLLLLSIVI LYCRIYSLVR TRSRRLTFRK NISKASRSSE KSLALLKTVI IVLSVFIACW APLFILLLLD VGCKAKTCDI LYKAEYFLVL AVLNSGTNPI IYTLTNKEMR RAFIRIISCC KCPNGDSAGK FKRPIIPGME FSRSKSDNSS HPQKDDGDNP ETIMSSGNVN SSS. It is sometimes possible for the material contained within the vial of "Sphingosine 1-phosphate receptor 1 (S1pr1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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