SDS-PAGE
Nogo Receptor / NOGOR / RTN4R Recombinant Protein | NOGOR recombinant protein
Recombinant Mouse Nogo Receptor / NOGOR / RTN4R Protein (His & Fc tag)
Gene Names
Rtn4r; NgR; NgR1; NOGOR
Purity
> 85 % as determined by SDS-PAGE
Synonyms
Nogo Receptor / NOGOR / RTN4R; Recombinant Mouse Nogo Receptor / NOGOR / RTN4R Protein (His & Fc tag); NOGOR; NgR; Rtn4r; NOGOR recombinant protein
Host
Human Cells
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
473
Application Notes
The recombinant mouse RTN4R/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 669 amino acids and has a predicted molecular mass of 73.8 kDa. Due to glycosylation, rmRTN4R/Fc monomer migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions.
Predicted N Terminal
Cys 27
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for NOGOR recombinant protein
Background: Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
Description: A DNA sequence encoding the the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
50,987 Da
NCBI Official Full Name
reticulon-4 receptor
NCBI Official Synonym Full Names
reticulon 4 receptor
NCBI Official Symbol
Rtn4r
NCBI Official Synonym Symbols
NgR; NgR1; NOGOR
NCBI Protein Information
reticulon-4 receptor
UniProt Protein Name
Reticulon-4 receptor
UniProt Gene Name
Rtn4r
UniProt Synonym Gene Names
Nogor; NgR
Uniprot Description
RTN4R: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development. Belongs to the Nogo receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 16|16 A3
Cellular Component: cell soma; cell surface; cytoplasm; endoplasmic reticulum; growth cone; integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: axonogenesis; cytokine and chemokine mediated signaling pathway; negative regulation of axon extension; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; positive regulation of GTPase activity
Disease: Schizophrenia
Research Articles on NOGOR
Similar Products
Product Notes
The NOGOR rtn4r (Catalog #AAA2547159) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse RTN4R/Fc chimera is a disulfide-linked homodimer. The reduced monomer consists of 669 amino acids and has a predicted molecular mass of 73.8 kDa. Due to glycosylation, rmRTN4R/Fc monomer migrates as an approximately 95-100 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the NOGOR rtn4r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nogo Receptor / NOGOR / RTN4R, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
