Regulator of telomere elongation helicase 1 (Rtel1) Recombinant Protein | Rtel1 recombinant protein

Recombinant Mouse Regulator of telomere elongation helicase 1 (Rtel1) , partial

• Gene Names: Rtel1; Rtel; AI451565; AW540478
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Regulator of telomere elongation helicase 1 (Rtel1); Recombinant Mouse Regulator of telomere elongation helicase 1 (Rtel1); partial; Rtel1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 527

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Rtel1 recombinant protein

In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. It is located in a gene-rich cluster on chromosome 20, with other potential tumor-related genes, such as TNFRSF6B. Multiple transcript variants encoding different isoforms have been described for this gene, although the full-length nature of not all variants is known.

NCBI and Uniprot Product Information

• NCBI GI #: 262263441
• NCBI GeneID: 269400
• NCBI Accession #: NP_001001882.3
• NCBI GenBank Nucleotide #: NM_001001882.3
• UniProt Accession #: Q0VGM9; Q3UM40; Q5F0J8; Q69ZS1; Q6H1L0; Q6H1L1; A2AU09; A2AU10; A2AU11; A2AU12; A2AU13; A2AU14
• Molecular Weight: 59,317 Da
• NCBI Official Full Name: regulator of telomere elongation helicase 1 isoform 1
• NCBI Official Synonym Full Names: regulator of telomere elongation helicase 1
• NCBI Official Symbol: Rtel1
• NCBI Official Synonym Symbols: Rtel; AI451565; AW540478
• NCBI Protein Information: regulator of telomere elongation helicase 1
• UniProt Protein Name: Regulator of telomere elongation helicase 1
• Protein Family: Regulator of telomere elongation helicase
• UniProt Gene Name: Rtel1
• UniProt Synonym Gene Names: Kiaa1088; Rtel

Uniprot Description

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.