Exosome complex exonuclease rrp6 (rrp6) Recombinant Protein | rrp6 recombinant protein

Recombinant Schizosaccharomyces pombe Exosome complex exonuclease rrp6 (rrp6), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Exosome complex exonuclease rrp6 (rrp6); Recombinant Schizosaccharomyces pombe Exosome complex exonuclease rrp6 (rrp6); partial; rrp6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 777

• Species: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 63054485
• NCBI GeneID: 2543630
• NCBI Accession #: NP_593004.2
• NCBI GenBank Nucleotide #: NM_001018403.2
• UniProt Accession #: Q10146
• Molecular Weight: 89,560 Da
• NCBI Official Full Name: exosome 3'-5' exoribonuclease subunit Rrp6 (predicted)
• NCBI Official Symbol: rrp6
• NCBI Protein Information: exosome 3'-5' exoribonuclease subunit Rrp6 (predicted)
• UniProt Protein Name: Exosome complex exonuclease rrp6
• Protein Family: Exosome complex exonuclease
• UniProt Gene Name: rrp6

Uniprot Description

Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site ().